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John T Manning Selected Research

American Hemorrhagic Fever (Bolivian Hemorrhagic Fever)

1/2022Machupo Virus with Mutations in the Transmembrane Domain and Glycosylation Sites of the Glycoprotein Is Attenuated and Immunogenic in Animal Models of Bolivian Hemorrhagic Fever.
1/2020The Glycoprotein of the Live-Attenuated Junin Virus Vaccine Strain Induces Endoplasmic Reticulum Stress and Forms Aggregates prior to Degradation in the Lysosome.
1/2017Absence of an N-Linked Glycosylation Motif in the Glycoprotein of the Live-Attenuated Argentine Hemorrhagic Fever Vaccine, Candid #1, Results in Its Improper Processing, and Reduced Surface Expression.
6/2015The glycoprotein precursor gene of Junin virus determines the virulence of the Romero strain and the attenuation of the Candid #1 strain in a representative animal model of Argentine hemorrhagic fever.

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John T Manning Research Topics

Disease

9Neoplasms (Cancer)
02/2014 - 05/2002
6Infections
01/2021 - 04/2005
4American Hemorrhagic Fever (Bolivian Hemorrhagic Fever)
01/2022 - 06/2015
4Lymphoma (Lymphomas)
04/2005 - 05/2002
3Leukemia
06/2015 - 09/2007
2Fever (Fevers)
01/2021 - 01/2018
2COVID-19
01/2021 - 12/2020
2Viral Hemorrhagic Fevers (Viral Hemorrhagic Fever)
01/2020 - 06/2015
2Lassa Fever (Fever, Lassa)
10/2019 - 01/2019
2Epstein-Barr Virus Infections
06/2017 - 08/2013
2B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
06/2017 - 06/2015
2Disease Progression
06/2015 - 01/2014
2Non-Hodgkin Lymphoma (Lymphosarcoma)
04/2005 - 06/2003
1Weight Loss (Weight Reduction)
01/2021
1Sinus Histiocytosis (Rosai-Dorfman Disease)
01/2019
1Sepsis (Septicemia)
06/2017
1Virus Diseases (Viral Diseases)
06/2017
1Hip Osteoarthritis (Coxarthrosis)
07/2014
1Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral)
02/2014
1Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma)
01/2014
1Lymphocytosis
09/2013
1Autoimmune Diseases (Autoimmune Disease)
08/2013
1Dermatomyositis (Dermatopolymyositis)
08/2013
1Crohn Disease (Crohn's Disease)
08/2013
1Autoimmune Hepatitis
08/2013
1Systemic Lupus Erythematosus (Libman-Sacks Disease)
08/2013
1Rheumatoid Arthritis
08/2013
1BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
06/2011
1Blast Crisis (Blast Phase)
06/2011
1Pericarditis
02/2011
1Interstitial Lung Diseases (Interstitial Lung Disease)
02/2011
1Bronchiolitis
02/2011
1Bronchiolitis Obliterans Syndrome
02/2011
1Aspergillosis
09/2007
1Mycoses (Diseases, Fungus)
09/2007
1Hematologic Neoplasms (Hematological Malignancy)
09/2007
1Lymphadenitis (Adenitis)
12/2004
1Hodgkin Disease (Hodgkin's Disease)
07/2003
1HIV Infections (HIV Infection)
07/2003
1Acquired Immunodeficiency Syndrome (AIDS)
07/2003
1Opportunistic Infections (Opportunistic Infection)
05/2002
1Lymphoproliferative Disorders (Lymphoproliferative Disorder)
05/2002

Drug/Important Bio-Agent (IBA)

6VaccinesIBA
01/2021 - 01/2017
3Glycoproteins (Glycoprotein)IBA
01/2022 - 06/2015
3MicroRNAs (MicroRNA)IBA
06/2017 - 09/2013
2CytokinesIBA
01/2021 - 12/2004
2Antiviral Agents (Antivirals)IBA
06/2015 - 05/2002
2Rituximab (Mabthera)FDA Link
04/2005 - 07/2003
1salicylanilideIBA
01/2021
1Polysaccharides (Glycans)IBA
01/2021
1SalicylanilidesIBA
01/2021
1Oxygen (Dioxygen)IBA
12/2020
1Angiotensin-Converting Enzyme 2IBA
12/2020
1Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
12/2020
1Attenuated VaccinesIBA
01/2020
1Cyclin D1IBA
01/2019
1DNA (Deoxyribonucleic Acid)IBA
01/2019
1S100 Proteins (S 100 Protein)IBA
01/2019
1AntibodiesIBA
01/2018
1Proteins (Proteins, Gene)FDA Link
06/2015
1RNA (Ribonucleic Acid)IBA
02/2014
1Granzymes (Granzyme)IBA
02/2014
1Capsules (Microcapsules)IBA
01/2014
1Immunologic Factors (Immunomodulators)IBA
08/2013
1Immunomodulating AgentsIBA
08/2013
1Methotrexate (Mexate)FDA LinkGeneric
08/2013
1Azathioprine (Imuran)FDA LinkGeneric
08/2013
1Thalidomide (Thalomid)FDA Link
08/2013
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
08/2013
1Dasatinib (BMS 354825)FDA Link
06/2011
1Immunoglobulins (Immunoglobulin)IBA
05/2010
1Anaplastic Lymphoma KinaseIBA
09/2009
1IronIBA
09/2007
1Peroxidase (Myeloperoxidase)IBA
05/2006
1Muramidase (Lysozyme)IBA
05/2006
1naphthol AS-D chloroacetateIBA
05/2006
1Cytarabine (Cytosar-U)FDA LinkGeneric
04/2005
1Carmustine (FIVB)FDA Link
04/2005
1Etoposide (VP 16)FDA LinkGeneric
04/2005
1Melphalan (Alkeran)FDA LinkGeneric
04/2005
1Melanins (Melanin)IBA
07/2003
1Alemtuzumab (Campath)FDA Link
05/2002
1fludarabineIBA
05/2002
1DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA
05/2002
1ChromatinIBA
05/2002

Therapy/Procedure

6Therapeutics
01/2021 - 05/2002
5Drug Therapy (Chemotherapy)
06/2017 - 04/2005
2Breast Implants (Breast Implant)
01/2014 - 09/2009
2Stem Cell Transplantation
02/2011 - 04/2005
1Replacement Arthroplasty
07/2014
1Immunomodulation
08/2013
1Cell Transplantation
02/2011
1Hematopoietic Stem Cell Transplantation
09/2007
1Radiotherapy
06/2003
1Combined Modality Therapy
06/2003